PredictionMachine.com's picks use the state-of-the-art Predictalator, which plays every game 50,000 times before it's actually played. This technology has been remarkable - picking over 70% against-the-spread with its Locks of the Week, over 62% with Paul's Picks in College Football, the NFL and the NCAA Tournament and going 11-0 against-the-spread in the 2011 NFL postseason. Prior to PredictionMachine.com, Paul Bessire developed sports investing into a lucrative profession and proved that by besting over 100 prognosticators in the inaugural Richard Gardner Pro Football Pick'em (against the spread) contest.

Paul's Picks, which include the top three ATS plays Sunday as well as the Monday Night play, are coming off a 4-0 ATS weekend and are now 12-4 ATS (75%) to start the season. Including last season, this brings our all-time record during football to 120-78 ATS (61%) for Paul's Picks, 86-45 ATS (66%) in ATS Top Plays of the Day and 33-15 ATS (69%) for Locks of the week.

Week 5 NFL Picks feature five picks that cover the spread greater than 60% of the time, including the Lock of the Week at 61.8% to cover the spread. Gain the edge you need with this week's picks.

In addition to gaining access to the free straight-up, against-the-spread and over/under picks from the Predictalator and Paul Bessire, you may sign up for email alerts on future content, see our free Fantasy Cheat Sheets and Power Rankings, play the games yourself with our Customizable Predictalator and have the ability to purchase current and future football straight-up, against-the-spread and over/under picks for every game. Sign up now.